Fig. 7From: Phospho-Tyr705 of STAT3 is a therapeutic target for sepsis through regulating inflammation and coagulationSchematic of the regulation of septic inflammation and coagulopathy in endothelial cells and macrophages by STAT3 signaling. a, b In macrophages, inhibition of pY-STAT3 reduces sepsis-induced proinflammatory mediators and TF expression through inactivation of JAK2/STAT3, NF-κB, MAPK and AKT signaling. c, d In endothelial cells, inhibition of pY-STAT3 protects cells from inflammatory injury and hyperpermeability via JAK2/STAT3, NF-κB, MAPK and AKT pathways and enhances cellular VE-cadherin/α-E-catenin localizationBack to article page