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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Phospho-Tyr705 of STAT3 is a therapeutic target for sepsis through regulating inflammation and coagulation

Fig. 1

BP but not Na, protects mice from septic death, systemic inflammation and coagulopathy. a Immunoblotting analysis of pulmonary STAT3 and phospho-Y705-STAT3 in mice 24 h after CLP or shame operation. b Immunoblotting analysis of pulmonary STAT3 and pY-STAT3 in mice 24 h after CLP with BP or Na administration (n = 3 per group). c Administration of BP, but not Na prevented CLP-induced mouse death (n = 12 mice per group; Kaplan-Meier survival analysis). d IL-1β, IL-6, TNF-α, CXCL10, TF, PAI1, TAT and D-Dimer concentrations in plasma were measured 24 h after the CLP procedure by ELISA (n ≥ 5 per group; two-tailed Student’s test). **P < 0.01 and *P < 0.05 (CLP versus Sham); ##P < 0.01 and #P < 0.05 (CLP versus CLP + BP); ns indicates not significant

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