ERK and Akt exhibit distinct signaling responses following stimulation by pro-angiogenic factors

Table 2 The total sensitivity index Sti values

	Parameter name	**Stivalues**^a		Description
	Parameter name	pERK	pAkt	Description
Only influential to pERK	*kd_dpRaf*	0.87	0.00	Dissociation rate of Raf_a and Ptase1
	[ERK]	0.84	0.08	Initial concentration of ERK
	*kd_aMEKRaf*	0.84	0.00	Dissociation rate of MEK and Raf_a
	*kd_RasGDP*	0.83	0.00	Ras-GTP activation rate
	[Ptase1]	0.80	0.03	Initial concentration of Ptase1
	*kf37*	0.77	0.06	pMEK phosphorylation rate via pFRS2
	*ked_MEKRaf2*	0.77	0.00	pMEK phosphorylation rate via aRaf
	[Ptase2]	0.73	0.10	Initial concentration of Ptase2
	*k_aERKMEK*	0.73	0.05	ERK/pERK and ppMEK association rate
Only influential to pAkt	[Akt]	0.21	0.83	Initial concentration of Akt
	[PI3K]	0.44	0.80	Initial concentration of PI3K
	*k_fPIP3*	0.04	0.78	PIP3 activation rate via pR2:pPI3K:PIP2
	[PP2Aoff]	0.08	0.76	Initial concentration of active PP2A
	[PIP2]	0.27	0.73	Initial concentration of PIP2
	[PTEN]	0.22	0.72	Initial concentration of PTEN
	[Ras-GDP]	0.35	0.71	Initial concentration of Ras-GDP
Influential to pERK and pAkt	[H]	0.87	0.79	Initial concentration of HSGAG
	[R2]	0.86	0.83	Initial concentration of VEGFR2
	*kf5a*	0.84	0.71	FGFR and FGF:HSGAG association rate
	[R]	0.83	0.79	Initial concentration of FGFR
	[FRS2]	0.78	0.73	Initial concentration of FRS2
	[MEK]*	0.76	0.67	Initial concentration of MEK
	*k_pR2*	0.75	0.80	VEGFR2 phosphorylation rate
	*kf0**	0.66	0.75	FGF and HSGAG association rate
	*k_1PI3K**	0.65	0.81	Association rate of pR2 and PI3K

^a The variables that have Sti values greater than 0.7 are considered as influential, but not very influential if their Sti values are lower than 0.5. In the category of influential to pERK and pAkt, [MEK], kf0, and k_1PI3K are labeled with asterisks as they do not strictly meet these criteria; they have Sti > 0.7 for one output and 0.6–0.7 for the other

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