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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Identification of a novel IL-5 signaling pathway in chronic pancreatitis and crosstalk with pancreatic tumor cells

Fig. 6

Proposed mechanism for IL-5 secretion and tumor migration. (1) Upon inflammation (2) pancreatic stellate cells become activated and secrete collagen and periostin. (3) Acinar cells begin to undergo acinar-to-ductal metaplasia and secrete IL-5, (4) which recruits eosinophils into the microenvironment. Eosinophils are retained in the microenvironment by periostin secreted pancreatic stellate cells. Prolonged inflammation further converts ADM cells into PanINs. PanIN lesions and pancreatic tumor cells express IL-5 receptor. (5) When IL-5 receptor is bound by IL-5, (6) STAT 5 signaling pathway is activated which leads to (7) tumor cell migration by a possible MMP dependent mechanism

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Cell Communication and Signaling

ISSN: 1478-811X