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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Remodelling of the bone marrow microenvironment by stromal hyaluronan modulates the malignancy of breast cancer cells

Fig. 1

Elevated deposition of HA in BM stroma. a. Micro-CT was used to scan the bone after MDA-MB-231BO cell intracardiac injection into the left ventricle of 4- to 6-week-old female nude mice. Arrows indicate the osteolytic areas in the control and treated groups. b. Immunohistochemical expression of HA in BM. Brown indicates HA. Representative images of each group are shown. Left scale bars, 100 μm; right scale bars, 50 μm. Tu: tumour, St: stroma. Scatter plots showing the levels of HA. c. Elevated HA in breast cancer-associated BM stroma was analysed by electrophoresis

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