Fig. 1From: CCL2/CCR2 signaling in cancer pathogenesisCrosstalk between tumor cells and pro-inflammatory factors in the tumor microenvironment further amplifies the extravasation of tumor cells. Tumor cells produce chemokines, such as CCL2, CCL7, CCL8 and CCL13 that drive the generation of multiple types of regulatory immune cells, including T cells, B cells and myeloid-derived suppressor cells (MDSCs), and promote further TAM development by enhancing the recruitment of macrophages to the tumor site. Immune Cells in the modified tumor microenvironment subsequently produce cytokines, chemokines and other molecules that promote immune escape of tumor cellsBack to article page