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Fig. 9 | Cell Communication and Signaling

Fig. 9

From: Exogenous fibroblast growth factor 1 ameliorates diabetes-induced cognitive decline via coordinately regulating PI3K/AKT signaling and PERK signaling

Fig. 9

PERK inhibitor blocks high glucose-induced neuronal apoptosis through inhibiting ER stress and enhancing CREB activity. a Cell viability of SH-SY5Y cells under high glucose with different concentrations of GSK2356157; b-d Western blotting and quantitative analysis of p-PERK and p-eIF2α expressions in SH-SY5Y cells under high glucose with or without different concentrations of GSK2356157; e-k Western blotting and quantitative analysis of p-PERK, p-eIF2α, BDNF, p-CREB (S133), PSD95, synaptophysin and Cleaved-Caspase 3 expressions in SH-SY5Y cells under high glucose treating with GSK or FGF1. GSK: GSK2356157. *p < 0.05 vs. the other two groups, n = 3. j A Schematic showing FGF1 ameliorates diabetes-induced cognitive dysfunction

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Cell Communication and Signaling

ISSN: 1478-811X