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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Exogenous fibroblast growth factor 1 ameliorates diabetes-induced cognitive decline via coordinately regulating PI3K/AKT signaling and PERK signaling

Fig. 7

FGF1 alleviates diabetes-induced suppression of CREB activity and BDNF expression via PI3K-AKT signaling and PERK signaling during DICD. a and b Immunofluorescence staining of BDNF and MAP 2 in the CA1 of hippocampus from db/m mice, db/db mice and db/db + FGF1-treated mice (Scale bar = 15 μm); (c-g) Western blotting and quantitative analysis of BDNF, p-AKT, p-GSKβ, p-CREB (S133) and p-CREB (S129) expressions in the hippocampus from mice. *p < 0.05 vs. the other two groups, n = 3

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