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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: AMPK activation overcomes anti-EGFR antibody resistance induced by KRAS mutation in colorectal cancer

Fig. 6

AMPK activation overcome Kras mutation induced drug resistance in vivo. a The growth of DLD1 WT and Kras mutated cell implanted xenograft tumor in response to 0.8 mg/kg Cet treatment (n = 6). b The expression of indicated proteins in representative tumors in the initial 5 days of treatment. c The TUNEl staining of tumor sample from (b). d The growth of DLD1 Kras mutated cell implanted xenograft tumor in response to 0.8 mg/kg Cet and/or 100 mg/kg metformine treatment (n = 6). e The expression of indicated proteins in representative tumors in the initial 5 days of treatment. f The TUNEl staining of tumor sample from (e). Panels b, c, e, f were repeated for 3 times. *, p < 0.05; **, p < 0.01, ***, p < 0.001

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