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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: The crosstalk: exosomes and lipid metabolism

Fig. 2

Lipid metabolism is involved in the biosynthesis and releases of exosomes, as well as its interaction with recipient cells. The transformation process from early endosomes to MVBs is induced by ceramide, cholesterol and PA. Then MVBs are either fused with lysosomes or with plasma membrane. And the fusion of MVBs with plasma membrane is promoted by ABCA1-mediated cholesterol efflux from the parent cells. The released exosomes deliver their contents to recipient cells through internalization, fusion with cell membrane or interaction with ligand on membrane. However, SR-B1-mediated cholesterol efflux inhibits the absorption of exosomes by recipient cells can be inhibited by SR-B1-mediated cholesterol efflux

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