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Table 3 Univariate and multivariate anayses for overall survival and progression-free survival in OCCCa/OHGSeCa

From: Upregulation of fibronectin following loss of p53 function is a poor prognostic factor in ovarian carcinoma with a unique immunophenotype

Univariate analysis

Multivariate analysis

Variables

Cutt-off

Log rank c2

p-value

factor

Variable

Cut-off

Hazard Ratio

95% CI

p-value

Overall survival

    

Overall survival

    

Fibronectin

2/3

4.9

0.02

High score

Fibronectin

2/3

2.6

1.2–5.4

0.01

p53

5/6

6.4

0.01

High score

p53

5/6

0.9

0.4–2.0

0.8

Histological type

OCCCa/OHGSeCa

11.2

0.0008

OHGSeCa

Histological type

OCCCa/OHGSeCa

0.4

0.2–1.1

0.07

Age

57/58

0.4

0.52

 

FIGO stage

I/II・III・V

0.2

0.06–0.7

0.01

FIGO stage

I/II・III・V

16.1

< 0.0001

II・III・IV

LN metastasis

−/+

0.8

0.4–1.5

0.5

Tumor size

11.1/11.2

1.1

0.3

 

Distant metastasis

−/+

0.7

0.3–1.6

0.4

LN metastasis

−/+

7.8

0.005

+

Residual tumor

Present/absent

0.6

0.3–1.2

0.2

Distant metastasis

−/+

8.9

0.002

+

after surgery

Residual tumor

Present/absent

8.1

0.004

Present

     

after surgery

     

Progression-free survival

   

Progression-free survival

   

Fibronectin

2/3

7.6

0.006

High score

Fibronectin

2/3

3.3

1.7–6.4

0.0005

p53

5/6

12.2

0.0005

High score

p53

5/6

1.3

0.6–2.8

0.6

Histological type

OCCCa/OHGSeCa

16.6

< 0.0001

OHSeGCa

Histological type

OCCCa/OHGSeCa

0.6

0.3–1.3

0.2

Age

57/58

3.9

0.04

58

Age

57/58

0.8

0.4–1.3

0.3

FIGO stage

I/II・III・V

32.7

< 0.0001

II・III・IV

FIGO stage

I/II・III・V

0.2

0.06–0.5

0.001

Tumor size

11.1/11.2

0.7

0.3

 

LN metastasis

−/+

0.7

0.4–1.2

0.2

LN metastasis

−/+

14.5

0.0001

+

Distant metastasis

−/+

0.5

0.2–0.9

0.03

Distant metastasis

−/+

22.1

< 0.0001

+

Residual tumor

Present/absent

0.7

0.4–1.3

0.3

Residual tumors

Present/absent

10

0.001

Present

after surgery

after surgery

     
  1. LN lymph node, n number of cases