Fig. 7From: Autophagy suppression of trophoblast cells induces pregnancy loss by activating decidual NK cytotoxicity and inhibiting trophoblast invasionInhibition of trophoblasts autophagy increases dNK cell killing activity and embryo absorption rate in vivo. a The mRNA expression of autophagy-associated molecules (LC3B, Beclin) was detected by qRT-PCR in placental. b At 8.5 days of pregnancy, the expression of NK killer receptors in the uterus were detected by FCM (Ctrl, n = 6, 3-MA, n = 6). c The mRNA expression of IGF-2 in placenta of mice was detected by qRT-PCR (Ctrl, n = 6; 3-MA, n = 6). d, e Embryo absorption rate of control group and 3-MA group (Ctrl, n = 12; 3-MA, n = 11). f The number of embryo implantations (Ctrl, n = 12; 3-MA, n = 12). g The weight of placenta and the embryo crown-rump length in both groups (Ctrl, n = 6; 3-MA, n = 6). The data are expressed as the mean ± SEM; unpaired t-test, Mann–Whitney, Chi-square test; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, NS: no significanceBack to article page