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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Autophagy suppression of trophoblast cells induces pregnancy loss by activating decidual NK cytotoxicity and inhibiting trophoblast invasion

Fig. 7

Inhibition of trophoblasts autophagy increases dNK cell killing activity and embryo absorption rate in vivo. a The mRNA expression of autophagy-associated molecules (LC3B, Beclin) was detected by qRT-PCR in placental. b At 8.5 days of pregnancy, the expression of NK killer receptors in the uterus were detected by FCM (Ctrl, n = 6, 3-MA, n = 6). c The mRNA expression of IGF-2 in placenta of mice was detected by qRT-PCR (Ctrl, n = 6; 3-MA, n = 6). d, e Embryo absorption rate of control group and 3-MA group (Ctrl, n = 12; 3-MA, n = 11). f The number of embryo implantations (Ctrl, n = 12; 3-MA, n = 12). g The weight of placenta and the embryo crown-rump length in both groups (Ctrl, n = 6; 3-MA, n = 6). The data are expressed as the mean ± SEM; unpaired t-test, Mann–Whitney, Chi-square test; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, NS: no significance

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