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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Autophagy suppression of trophoblast cells induces pregnancy loss by activating decidual NK cytotoxicity and inhibiting trophoblast invasion

Fig. 4

Autophagy in trophoblasts inhibits NK cell killing activity by IGF-2. a Heatmap of the differential genes associated with NCR1 and IFNG in control and ATG5-RNAi group. b, c dNK cells (n = 6) were co-cultured with trophoblasts pretreated by rapamycin or solvent control, with or without IGF-2 (50 ng/ul). The expressions of killing receptors in dNK cells were detected by FCM. d. Potential molecular pathways between autophagy and IGF-2 were predicted by bioinformatics analysis. e Immunohistochemistry analysis of IGF-2 expression in villi from normal pregnancy wowen (n = 5) and RSA patients (n = 5). Original magnification: × 200. The data are expressed as the mean ± SEM; one-way ANOVA; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, NS: no significance

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