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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: CLPTM1L induces estrogen receptor β signaling-mediated radioresistance in non-small cell lung cancer cells

Fig. 8

Silencing of CLPTM1L sensitizes xenograft NSCLC tumors to IR in an animal model. a Mice (n = 40) bearing NSCLC xenograft tumors developed from H460 or A549 cells transfected with control or CLPTM1L shRNA were treated with or without local IR, as illustrated in the diagram. b Growth of tumors generated by transplantation of NSCLC cells. c Images of dissected tumors from nude mice (n = 5/group). d Weight of resected xenograft tumors in nude mice. e Representative images (400× magnification) of H460 and A549 xenografts stained for CLPTM1L and Ki-67. f Real-time PCR analysis of the mRNA levels of CDC25A, c-Jun, and BCL2 in H460 and A549 xenografts. Statistically significant differences are indicated. NS, not significant. Student’s t test; * P < 0.05; ** P < 0.01. g The model shows that IR can increase the expression of CLPTM1L, and CLPTM1L upregulates the expression of ERβ-induced genes by coactivating ERβ via the LXXLL motif, leading to the radioresistance of NSCLC cells

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