From: The role of Neurotensin and its receptors in non-gastrointestinal cancers: a review
Site of cancer | In-vitro | Animal models | Prognostic/Predictive studies | Clinical trials |
---|---|---|---|---|
Lung (NSCLC) | Treatment with NT increased growth in LMN-R cells | NTSR1 blockade potentiates effect of geftinib | NTSR3 good prognostic marker | Afatinib in stage IV bronchial adenocarcinoma |
NTSR1 in cytoplasm a.w. poor prognosis | ||||
NTSR1 predicts worse sensitivity to platinum based treatments | ||||
NTSR2 expression has no correlation to OS | ||||
Pleural mesothelioma | NTSR1 antagonist reduced cell invasion in MSTO-211H cells | Â | High NT expression is an independent predictor of poor 5-year survival | Â |
NTSR1 had no impact of survival | ||||
Pancreas | NTSR1 promotes DNA synthesis, proliferation, angiogenesis | Â | NTSR1 increases with stage of disease | NI |
NTSR3 increases migration in individually migrating PDAC cells | ||||
Breast | Â | NTSR1 antagonist arrested tumour growth in xenografted MDA-MB-231 cells | High NTSR1 in patients with IDCs correlated to higher histoprognostic grade, larger tumour size and higher number of positive lymph nodes | NI |
Suicide HSVtk gene delivery by NT-polyplex nanoparticles + ganciclovir to treat MDA-MB-231 cells | ||||
High NTSR1 expression is associated with worse survival | ||||
Prostate | NT/NTSR1 in PC3 cells stimulates EGFR/ERK/Akt phosphorylation and DNA synthesis which is PKC-dependent | (64) Cu chelators conjugated to a NT analog was assessed as an imaging marker using PET/CT to was correlated to NTSR1-positive lesions Use of Lu-177-labelled NTSR1 antagonists in PSMA negative and NTSR1 positive prostate cancer nude mice showed reduced tumour growth over 57 days | There is more frequent NTSR1 overexpression in metastatic lymph nodes compared to primary tumours |  |
NTSR1 is found in poorly differentiated (androgen receptor negative) NTSR2 was found in well-differentiated cell lines | ||||
NTSR3 found in all cell lines | ||||
HNSCC | Addition of NT promoted invasion and migration. Knockdown of NTSR1 slowed invasion and migration | NI | High mRNA expression of NT and NTSR1 has a worse metastasis-free survival rate | NI |
Glioma Glioblastoma multiforme (GBM) | NT stimulates ERK1/2 phosphorylation | NTSR1 blockade in xenografted nude mice increased survival | NI | NI |
Different GBM cell lines express different NT receptors | NI | NI | NI | |
Studies on glioblastoma stem cells show that NT acts through the CXCR1/2/IL-8 pathway which is EGFR-dependent | Â | Â | Â |