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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: MACC1 driven alterations in cellular biomechanics facilitate cell motility in glioblastoma

Fig. 2

MACC1 influences the formation and structure of 3D aggregate formation. a, b MACC1 dependent size measurement of U138 and U251 3D aggregates. While MACC1 overexpression in U138 cells led to larger aggregates, this effect was not visible in U251 spheroids. c Evaluation of the occurrence of an “outer rim” in U251 and U138 3D aggregates. These structures are relevant for U251 aggregates only. d Proportion of the “outer rim” relative to the whole 3D aggregates of U251/EV and U251/MACC1 cells. MACC1 overexpression led to a reduced formation of dense ring structures. The following numbers of 3D aggregates were measured in three independent experiments: nU138/EV = 99, nU138/MACC1 = 46, nU251/EV = 22 and nU251/MACC1 = 52

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