Fig. 1
From: MACC1 driven alterations in cellular biomechanics facilitate cell motility in glioblastoma
MACC1 increases cell motility and the elastic modulus, and reduces the cell-surface contact. a Verification of MACC1 overexpression in U251/MACC1 and U138/MACC1 cells. b MACC1 overexpression led to a higher motility in U251 and U138 cells, which could be inhibited by crizotinib. c MACC1 overexpression led to a lower contact area of both U251 and U138 cells. Crizotinib application reversed the effect leading to an increase in contact area. The following numbers of cells were measured in three independent experiments (b and c): nU138/EV = 67, nU138/MACC1 = 164, nU138/MACC1 + Cri = 102, nU251/EV = 51, nU251/MACC1 = 51 and nU251/MACC1 + Cri = 45. D) MACC1 overexpression resulted in an increase of the Young’s modulus in U251 and U138 cells, which could be inhibited by crizotinib. The following numbers of cells were measured in three independent experiments: nU138/EV = 60, nU138/MACC1 = 85, nU138/MACC1 + Cri = 88, nU251/EV = 34, nU251/MACC1 = 32 and nU251/MACC1 + Cri = 35. Stars depict p < 0.05. Error bars depict the standard error of the mean