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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: TRPP2 and STIM1 form a microdomain to regulate store-operated Ca2+ entry and blood vessel tone

Fig. 7

Role of TRPP2 and STIM1 in agonist-induced mouse aorta contraction. Phenylephrine (10 μmol/L, a, b, e, f) and endothelin 1 (100 nmol/L, c, d, g, h) concentration-dependently induced the contraction of the mice aortae transfected with TRPP2 (a-d), STIM1 (e-h) or scrambled siRNA. b, d, f, h The mice aortae were pretreated by heparin (1 mg/ml) using a reversible permeabilization loading procedure. Values are shown as mean ± SEM (n = 4–6 mice). *P < 0.05 for scrambled siRNA vs. TRPP2 or STIM1 siRNA transfection

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