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Table 2 Univariate and multivariate analyses of clinicopathologic parameters associated with recurrence-free survival and overall survival

From: Wnt5a-induced M2 polarization of tumor-associated macrophages via IL-10 promotes colorectal cancer progression

ParametersRecurrence-free survivalOverall survival
Univariate analysisMultivariate analysisUnivariate analysisMultivariate analysis
HR95% CIPHR95% CIPHR95% CIPHR95% CIP
Gender (Male vs. Female)0.7820.391–1.5640.488   0.670.321–1.4000.287   
Age (≥60 years vs. <60 years)0.6390.325–1.2550.194   0.6410.316–1.3030.219   
Tumor site (Colon vs. Rectum)1.0150.515–2.0010.965   1.4180.700–2.8760.332   
Tumor size (<5 cm vs. ≥ 5 cm)1.2550.627–2.5120.521   1.4740.721–3.0160.288   
Tumor grade (Well vs Moderate vs Poor)1.7550.894–3.4460.102   1.2630.623–2.5640.517   
LVI (Absence vs. Presence)2.1341.051–4.3330.0361.9980.937–4.2570.0732.511.178–5.3500.0172.3361.040–5.2510.040
PI (Absence vs. Presence)1.5570.793–3.0590.198   1.9550.957–3.9970.066   
TI (T1–2 vs. T3–4)2.2881.299–4.0290.0041.3350.686–2.5970.3941.9261.094–3.3900.0231.1040.562–2.1680.774
LNM (N0–1 vs. N2–3)1.4641.070–2.0020.0170.6480.366–1.1470.1361.3871.001–1.9210.0490.6300.348–1.1390.126
TNM stage# (I vs. II vs. III)3.4231.702–6.8870.0015.1331.246–21.1560.0242.8841.428–5.8230.0034.6931.101–20.0110.037
CEA (≥ 5 ng/ml vs. <5 ng/ml)0.7910.377–1.6570.533   0.5290.227–1.2310.14   
CD68+ macrophage (Low vs. High)1.7850.901–3.5370.097   1.4650.722–2.9750.29   
Wnt5a+CD68+ macrophage (Low vs. High)2.2041.088–4.4650.0280.9810.441–2.1820.9622.1841.045–4.5630.0380.9250.404–2.1150.853
Wnt5a+CD68+/CD68+ macrophage (Low vs. High)4.5962.126–9.935< 0.0012.6981.110–6.5590.0294.3471.934–9.772< 0.0012.8091.107–7.1280.030
  1. Notes: Bold indicates P < 0.05; #The 7th edition of the AJCC Cancer Staging Manual. Abbreviations: LVI Lymphovascular invasion; PNI Perineural invasion; TI Tumor invasion; LNM Lymph node metastasis; TNM, tumor-node-metastasis; CEA Carcinoembryonic antigen; CD68 Cluster of differentiation 68; Wnt5a Wingless-type MMTV integration site family, member 5a