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Table 2 Univariate and multivariate analyses of clinicopathologic parameters associated with recurrence-free survival and overall survival

From: Wnt5a-induced M2 polarization of tumor-associated macrophages via IL-10 promotes colorectal cancer progression

Parameters

Recurrence-free survival

Overall survival

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

HR

95% CI

P

HR

95% CI

P

HR

95% CI

P

HR

95% CI

P

Gender (Male vs. Female)

0.782

0.391–1.564

0.488

   

0.67

0.321–1.400

0.287

   

Age (≥60 years vs. <60 years)

0.639

0.325–1.255

0.194

   

0.641

0.316–1.303

0.219

   

Tumor site (Colon vs. Rectum)

1.015

0.515–2.001

0.965

   

1.418

0.700–2.876

0.332

   

Tumor size (<5 cm vs. ≥ 5 cm)

1.255

0.627–2.512

0.521

   

1.474

0.721–3.016

0.288

   

Tumor grade (Well vs Moderate vs Poor)

1.755

0.894–3.446

0.102

   

1.263

0.623–2.564

0.517

   

LVI (Absence vs. Presence)

2.134

1.051–4.333

0.036

1.998

0.937–4.257

0.073

2.51

1.178–5.350

0.017

2.336

1.040–5.251

0.040

PI (Absence vs. Presence)

1.557

0.793–3.059

0.198

   

1.955

0.957–3.997

0.066

   

TI (T1–2 vs. T3–4)

2.288

1.299–4.029

0.004

1.335

0.686–2.597

0.394

1.926

1.094–3.390

0.023

1.104

0.562–2.168

0.774

LNM (N0–1 vs. N2–3)

1.464

1.070–2.002

0.017

0.648

0.366–1.147

0.136

1.387

1.001–1.921

0.049

0.630

0.348–1.139

0.126

TNM stage# (I vs. II vs. III)

3.423

1.702–6.887

0.001

5.133

1.246–21.156

0.024

2.884

1.428–5.823

0.003

4.693

1.101–20.011

0.037

CEA (≥ 5 ng/ml vs. <5 ng/ml)

0.791

0.377–1.657

0.533

   

0.529

0.227–1.231

0.14

   

CD68+ macrophage (Low vs. High)

1.785

0.901–3.537

0.097

   

1.465

0.722–2.975

0.29

   

Wnt5a+CD68+ macrophage (Low vs. High)

2.204

1.088–4.465

0.028

0.981

0.441–2.182

0.962

2.184

1.045–4.563

0.038

0.925

0.404–2.115

0.853

Wnt5a+CD68+/CD68+ macrophage (Low vs. High)

4.596

2.126–9.935

< 0.001

2.698

1.110–6.559

0.029

4.347

1.934–9.772

< 0.001

2.809

1.107–7.128

0.030

  1. Notes: Bold indicates P < 0.05; #The 7th edition of the AJCC Cancer Staging Manual. Abbreviations: LVI Lymphovascular invasion; PNI Perineural invasion; TI Tumor invasion; LNM Lymph node metastasis; TNM, tumor-node-metastasis; CEA Carcinoembryonic antigen; CD68 Cluster of differentiation 68; Wnt5a Wingless-type MMTV integration site family, member 5a
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Cell Communication and Signaling

ISSN: 1478-811X