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Table 1 Correlation between the ratio of Wnt5a+CD68+/CD68+ macrophages and clinicopathologic parameters (n = 63)

From: Wnt5a-induced M2 polarization of tumor-associated macrophages via IL-10 promotes colorectal cancer progression

Parametersn (%)Wnt5a+CD68+/CD68+ ratio (n)χ2 valueP value
Low (n = 32)High (n = 31)
Gender   0.0240.877
 Male38 (60.32)1919  
 Female25 (39.68)1312  
Age (years)   1.9050.167
 <6029 (46.03)1217  
  ≥ 6034 (53.97)2014  
Tumor site   0.0130.910
 Colon35 (55.56)1817  
 Rectum28 (44.44)1414  
Tumor size (cm)   0.3860.535
 <541 (65.08)2219  
  ≥ 522 (34.92)1012  
Tumor grade   1.9320.165
 Poor38 (60.32)2216  
 Moderate/Well25 (39.68)1015  
LVI   5.7730.016
 Absence30 (47.62)2010  
 Presence33 (52.38)1221  
PNI   1.9050.167
 Absence34 (53.97)2014  
 Presence29 (46.03)1217  
TI   6.7190.010
 T1–215 (23.81)123  
 T3–448 (76.19)2028  
LNM   7.0140.008
 N0–131 (49.21)2110  
 N2–332 (50.79)1121  
TNM stage#   9.9080.002
 I/II33 (52.38)2310  
 III30 (47.62)921  
CEA (ng/ml)   0.1280.721
 <544 (69.84)2321  
  ≥ 519 (30.16)910  
  1. Notes: Bold indicates P < 0.05; #The 7th edition of the AJCC Cancer Staging Manual. Abbreviations: LVI Lymphovascular invasion; PNI Perineural invasion; TI, tumor invasion; LNM Lymph node metastasis; TNM Tumor-node-metastasis; CEA carcinoembryonic antigen; CD68 Cluster of differentiation 68; Wnt5a Wingless-type MMTV integration site family, member 5a