TY - JOUR AU - Wan, L. AU - Pantel, K. AU - Kang, Y. PY - 2013 DA - 2013// TI - Tumor metastasis: moving new biological insights into the clinic JO - Nat Med VL - 19 UR - https://doi.org/10.1038/nm.3391 DO - 10.1038/nm.3391 ID - Wan2013 ER - TY - JOUR AU - Quail, D. F. AU - Joyce, J. A. PY - 2013 DA - 2013// TI - Microenvironmental regulation of tumor progression and metastasis JO - Nat Med VL - 19 UR - https://doi.org/10.1038/nm.3394 DO - 10.1038/nm.3394 ID - Quail2013 ER - TY - JOUR AU - Lopez-Soto, A. AU - Gonzalez, S. AU - Smyth, M. J. AU - Galluzzi, L. PY - 2017 DA - 2017// TI - Control of metastasis by NK cells JO - Cancer Cell VL - 32 UR - https://doi.org/10.1016/j.ccell.2017.06.009 DO - 10.1016/j.ccell.2017.06.009 ID - Lopez-Soto2017 ER - TY - JOUR AU - Maman, S. AU - Witz, I. P. PY - 2018 DA - 2018// TI - A history of exploring cancer in context JO - Nat Rev Cancer VL - 18 UR - https://doi.org/10.1038/s41568-018-0006-7 DO - 10.1038/s41568-018-0006-7 ID - Maman2018 ER - TY - JOUR AU - Jiang, Y. AU - Li, Y. AU - Zhu, B. PY - 2015 DA - 2015// TI - T-cell exhaustion in the tumor microenvironment JO - Cell Death Dis VL - 6 UR - https://doi.org/10.1038/cddis.2015.162 DO - 10.1038/cddis.2015.162 ID - Jiang2015 ER - TY - JOUR AU - Noy, R. AU - Pollard, J. W. PY - 2014 DA - 2014// TI - Tumor-associated macrophages: from mechanisms to therapy JO - Immunity. VL - 41 UR - https://doi.org/10.1016/j.immuni.2014.06.010 DO - 10.1016/j.immuni.2014.06.010 ID - Noy2014 ER - TY - JOUR AU - Condeelis, J. AU - Pollard, J. W. PY - 2006 DA - 2006// TI - Macrophages: obligate partners for tumor cell migration, invasion, and metastasis JO - Cell. VL - 124 UR - https://doi.org/10.1016/j.cell.2006.01.007 DO - 10.1016/j.cell.2006.01.007 ID - Condeelis2006 ER - TY - JOUR AU - Wei, C. AU - Yang, C. AU - Wang, S. AU - Shi, D. AU - Zhang, C. AU - Lin, X. PY - 2019 DA - 2019// TI - Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis JO - Mol Cancer VL - 18 UR - https://doi.org/10.1186/s12943-019-0976-4 DO - 10.1186/s12943-019-0976-4 ID - Wei2019 ER - TY - JOUR AU - Lin, X. AU - Wang, S. AU - Sun, M. AU - Zhang, C. AU - Wei, C. AU - Yang, C. PY - 2019 DA - 2019// TI - miR-195-5p/NOTCH2-mediated EMT modulates IL-4 secretion in colorectal cancer to affect M2-like TAM polarization JO - J Hematol Oncol VL - 12 UR - https://doi.org/10.1186/s13045-019-0708-7 DO - 10.1186/s13045-019-0708-7 ID - Lin2019 ER - TY - JOUR AU - Ruffell, B. AU - Affara, N. I. AU - Coussens, L. M. PY - 2012 DA - 2012// TI - Differential macrophage programming in the tumor microenvironment JO - Trends Immunol VL - 33 UR - https://doi.org/10.1016/j.it.2011.12.001 DO - 10.1016/j.it.2011.12.001 ID - Ruffell2012 ER - TY - JOUR AU - Chen, Y. AU - Zhang, S. AU - Wang, Q. AU - Zhang, X. PY - 2017 DA - 2017// TI - Tumor-recruited M2 macrophages promote gastric and breast cancer metastasis via M2 macrophage-secreted CHI3L1 protein JO - J Hematol Oncol VL - 10 UR - https://doi.org/10.1186/s13045-017-0408-0 DO - 10.1186/s13045-017-0408-0 ID - Chen2017 ER - TY - JOUR AU - Su, S. AU - Liu, Q. AU - Chen, J. AU - Chen, J. AU - Chen, F. AU - He, C. PY - 2014 DA - 2014// TI - A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis JO - Cancer Cell VL - 25 UR - https://doi.org/10.1016/j.ccr.2014.03.021 DO - 10.1016/j.ccr.2014.03.021 ID - Su2014 ER - TY - JOUR AU - Mantovani, A. AU - Sozzani, S. AU - Locati, M. AU - Allavena, P. AU - Sica, A. PY - 2002 DA - 2002// TI - Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes JO - Trends Immunol VL - 23 UR - https://doi.org/10.1016/S1471-4906(02)02302-5 DO - 10.1016/S1471-4906(02)02302-5 ID - Mantovani2002 ER - TY - JOUR AU - Ye, Y. C. AU - Zhao, J. L. AU - Lu, Y. T. AU - Gao, C. C. AU - Yang, Y. AU - Liang, S. Q. PY - 2019 DA - 2019// TI - NOTCH signaling via WNT regulates the proliferation of alternative, CCR2-independent tumor-associated macrophages in hepatocellular carcinoma JO - Cancer Res VL - 79 UR - https://doi.org/10.1158/0008-5472.CAN-18-1691 DO - 10.1158/0008-5472.CAN-18-1691 ID - Ye2019 ER - TY - JOUR AU - Yang, Y. AU - Ye, Y. C. AU - Chen, Y. AU - Zhao, J. L. AU - Gao, C. C. AU - Han, H. PY - 2018 DA - 2018// TI - Crosstalk between hepatic tumor cells and macrophages via Wnt/beta-catenin signaling promotes M2-like macrophage polarization and reinforces tumor malignant behaviors JO - Cell Death Dis VL - 9 UR - https://doi.org/10.1038/s41419-018-0818-0 DO - 10.1038/s41419-018-0818-0 ID - Yang2018 ER - TY - JOUR AU - Chae, W. J. AU - Bothwell, A. L. M. PY - 2018 DA - 2018// TI - Canonical and non-canonical Wnt signaling in immune cells JO - Trends Immunol VL - 39 UR - https://doi.org/10.1016/j.it.2018.08.006 DO - 10.1016/j.it.2018.08.006 ID - Chae2018 ER - TY - STD TI - Asem MS, Buechler S, Wates RB, Miller DL, Stack MS. Wnt5a Signaling in Cancer. Cancers (Basel). 2016;8(9). ID - ref17 ER - TY - JOUR AU - Chirumbolo, S. AU - Bjorklund, G. PY - 2016 DA - 2016// TI - Can Wnt5a and Wnt non-canonical pathways really mediate adipocyte de-differentiation in a tumour microenvironment? JO - Eur J Cancer VL - 64 UR - https://doi.org/10.1016/j.ejca.2016.05.026 DO - 10.1016/j.ejca.2016.05.026 ID - Chirumbolo2016 ER - TY - JOUR AU - Valencia, J. AU - Hernandez-Lopez, C. AU - Martinez, V. G. AU - Hidalgo, L. AU - Zapata, A. G. AU - Vicente, A. PY - 2011 DA - 2011// TI - Wnt5a skews dendritic cell differentiation to an unconventional phenotype with tolerogenic features JO - J Immunol VL - 187 UR - https://doi.org/10.4049/jimmunol.1101243 DO - 10.4049/jimmunol.1101243 ID - Valencia2011 ER - TY - JOUR AU - Feng, Y. AU - Liang, Y. AU - Zhu, X. AU - Wang, M. AU - Gui, Y. AU - Lu, Q. PY - 2018 DA - 2018// TI - The signaling protein Wnt5a promotes TGFbeta1-mediated macrophage polarization and kidney fibrosis by inducing the transcriptional regulators yap/Taz JO - J Biol Chem VL - 293 UR - https://doi.org/10.1074/jbc.RA118.005457 DO - 10.1074/jbc.RA118.005457 ID - Feng2018 ER - TY - JOUR AU - Ziegler, S. AU - Gartner, K. AU - Scheuermann, U. AU - Zoeller, T. AU - Hantzschmann, J. AU - Over, B. PY - 2014 DA - 2014// TI - Ca (2+) -related signaling events influence TLR9-induced IL-10 secretion in human B cells JO - Eur J Immunol VL - 44 UR - https://doi.org/10.1002/eji.201343994 DO - 10.1002/eji.201343994 ID - Ziegler2014 ER - TY - JOUR AU - Pukrop, T. AU - Klemm, F. AU - Hagemann, T. AU - Gradl, D. AU - Schulz, M. AU - Siemes, S. PY - 2006 DA - 2006// TI - Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell lines JO - Proc Natl Acad Sci U S A VL - 103 UR - https://doi.org/10.1073/pnas.0509703103 DO - 10.1073/pnas.0509703103 ID - Pukrop2006 ER - TY - JOUR AU - Nitzki, F. AU - Zibat, A. AU - Konig, S. AU - Wijgerde, M. AU - Rosenberger, A. AU - Brembeck, F. H. PY - 2010 DA - 2010// TI - Tumor stroma-derived Wnt5a induces differentiation of basal cell carcinoma of Ptch-mutant mice via CaMKII JO - Cancer Res VL - 70 UR - https://doi.org/10.1158/0008-5472.CAN-09-3743 DO - 10.1158/0008-5472.CAN-09-3743 ID - Nitzki2010 ER - TY - JOUR AU - Smith, K. AU - Bui, T. D. AU - Poulsom, R. AU - Kaklamanis, L. AU - Williams, G. AU - Harris, A. L. PY - 1999 DA - 1999// TI - Up-regulation of macrophage wnt gene expression in adenoma-carcinoma progression of human colorectal cancer JO - Br J Cancer VL - 81 UR - https://doi.org/10.1038/sj.bjc.6690721 DO - 10.1038/sj.bjc.6690721 ID - Smith1999 ER - TY - JOUR AU - Bergenfelz, C. AU - Medrek, C. AU - Ekstrom, E. AU - Jirstrom, K. AU - Janols, H. AU - Wullt, M. PY - 2012 DA - 2012// TI - Wnt5a induces a tolerogenic phenotype of macrophages in sepsis and breast cancer patients JO - J Immunol VL - 188 UR - https://doi.org/10.4049/jimmunol.1103378 DO - 10.4049/jimmunol.1103378 ID - Bergenfelz2012 ER - TY - JOUR AU - Zhang, B. AU - Ye, H. AU - Ren, X. AU - Zheng, S. AU - Zhou, Q. AU - Chen, C. PY - 2019 DA - 2019// TI - Macrophage-expressed CD51 promotes cancer stem cell properties via the TGF-beta1/smad2/3 axis in pancreatic cancer JO - Cancer Lett VL - 459 UR - https://doi.org/10.1016/j.canlet.2019.06.005 DO - 10.1016/j.canlet.2019.06.005 ID - Zhang2019 ER - TY - JOUR AU - Chen, F. F. AU - Wang, S. Y. AU - Fang, Y. AU - Zheng, L. AU - Zhi, X. AU - Cheng, B. R. PY - 2017 DA - 2017// TI - Feasibility of a novel one-stop ISET device to capture CTCs and its clinical application JO - Oncotarget. VL - 8 ID - Chen2017 ER - TY - JOUR AU - Huang, Y. J. AU - Yang, C. K. AU - Wei, P. L. AU - Huynh, T. T. AU - Whang-Peng, J. AU - Meng, T. C. PY - 2017 DA - 2017// TI - Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways JO - J Hematol Oncol VL - 10 UR - https://doi.org/10.1186/s13045-017-0421-3 DO - 10.1186/s13045-017-0421-3 ID - Huang2017 ER - TY - JOUR AU - Zhang, G. AU - Guo, L. AU - Yang, C. AU - Liu, Y. AU - He, Y. AU - Du, Y. PY - 2016 DA - 2016// TI - A novel role of breast cancer-derived hyaluronan on inducement of M2-like tumor-associated macrophages formation JO - Oncoimmunology. VL - 5 UR - https://doi.org/10.1080/2162402X.2016.1172154 DO - 10.1080/2162402X.2016.1172154 ID - Zhang2016 ER - TY - JOUR AU - Lee, J. H. AU - Lee, G. T. AU - Woo, S. H. AU - Ha, Y. S. AU - Kwon, S. J. AU - Kim, W. J. PY - 2013 DA - 2013// TI - BMP-6 in renal cell carcinoma promotes tumor proliferation through IL-10-dependent M2 polarization of tumor-associated macrophages JO - Cancer Res VL - 73 UR - https://doi.org/10.1158/0008-5472.CAN-12-4563 DO - 10.1158/0008-5472.CAN-12-4563 ID - Lee2013 ER - TY - JOUR AU - Zhong, W. AU - Chebolu, S. AU - Darmani, N. A. PY - 2016 DA - 2016// TI - Thapsigargin-induced activation of Ca (2+)-CaMKII-ERK in brainstem contributes to substance P release and induction of emesis in the least shrew JO - Neuropharmacology. VL - 103 UR - https://doi.org/10.1016/j.neuropharm.2015.11.023 DO - 10.1016/j.neuropharm.2015.11.023 ID - Zhong2016 ER - TY - JOUR AU - Hamm, A. AU - Prenen, H. AU - Delm, W. AU - Matteo, M. AU - Wenes, M. AU - Delamarre, E. PY - 2016 DA - 2016// TI - Tumour-educated circulating monocytes are powerful candidate biomarkers for diagnosis and disease follow-up of colorectal cancer JO - Gut. VL - 65 UR - https://doi.org/10.1136/gutjnl-2014-308988 DO - 10.1136/gutjnl-2014-308988 ID - Hamm2016 ER - TY - JOUR AU - Yuan, Z. Y. AU - Luo, R. Z. AU - Peng, R. J. AU - Wang, S. S. AU - Xue, C. PY - 2014 DA - 2014// TI - High infiltration of tumor-associated macrophages in triple-negative breast cancer is associated with a higher risk of distant metastasis JO - Onco Targets Ther VL - 7 UR - https://doi.org/10.2147/OTT.S61838 DO - 10.2147/OTT.S61838 ID - Yuan2014 ER - TY - JOUR AU - Ryder, M. AU - Ghossein, R. A. AU - Ricarte-Filho, J. C. AU - Knauf, J. A. AU - Fagin, J. A. PY - 2008 DA - 2008// TI - Increased density of tumor-associated macrophages is associated with decreased survival in advanced thyroid cancer JO - Endocr Relat Cancer VL - 15 UR - https://doi.org/10.1677/ERC-08-0036 DO - 10.1677/ERC-08-0036 ID - Ryder2008 ER - TY - JOUR AU - Funada, Y. AU - Noguchi, T. AU - Kikuchi, R. AU - Takeno, S. AU - Uchida, Y. AU - Gabbert, H. E. PY - 2003 DA - 2003// TI - Prognostic significance of CD8+ T cell and macrophage peritumoral infiltration in colorectal cancer JO - Oncol Rep VL - 10 ID - Funada2003 ER - TY - JOUR AU - Forssell, J. AU - Oberg, A. AU - Henriksson, M. L. AU - Stenling, R. AU - Jung, A. AU - Palmqvist, R. PY - 2007 DA - 2007// TI - High macrophage infiltration along the tumor front correlates with improved survival in colon cancer JO - Clin Cancer Res VL - 13 UR - https://doi.org/10.1158/1078-0432.CCR-06-2073 DO - 10.1158/1078-0432.CCR-06-2073 ID - Forssell2007 ER - TY - JOUR AU - Braster, R. AU - Bogels, M. AU - Beelen, R. H. AU - Egmond, M. PY - 2017 DA - 2017// TI - The delicate balance of macrophages in colorectal cancer; their role in tumour development and therapeutic potential JO - Immunobiology. VL - 222 UR - https://doi.org/10.1016/j.imbio.2015.08.011 DO - 10.1016/j.imbio.2015.08.011 ID - Braster2017 ER - TY - JOUR AU - He, K. F. AU - Zhang, L. AU - Huang, C. F. AU - Ma, S. R. AU - Wang, Y. F. AU - Wang, W. M. PY - 2014 DA - 2014// TI - CD163+ tumor-associated macrophages correlated with poor prognosis and cancer stem cells in oral squamous cell carcinoma JO - Biomed Res Int VL - 2014 ID - He2014 ER - TY - JOUR AU - Park, J. Y. AU - Sung, J. Y. AU - Lee, J. AU - Park, Y. K. AU - Kim, Y. W. AU - Kim, G. Y. PY - 2016 DA - 2016// TI - Polarized CD163+ tumor-associated macrophages are associated with increased angiogenesis and CXCL12 expression in gastric cancer JO - Clin Res Hepatol Gastroenterol VL - 40 UR - https://doi.org/10.1016/j.clinre.2015.09.005 DO - 10.1016/j.clinre.2015.09.005 ID - Park2016 ER - TY - JOUR AU - Cortes, M. AU - Sanchez-Moral, L. AU - Barrios, O. AU - Fernandez-Acenero, M. J. AU - Martinez-Campanario, M. C. AU - Esteve-Codina, A. PY - 2017 DA - 2017// TI - Tumor-associated macrophages (TAMs) depend on ZEB1 for their cancer-promoting roles JO - EMBO J VL - 36 UR - https://doi.org/10.15252/embj.201797345 DO - 10.15252/embj.201797345 ID - Cortes2017 ER - TY - JOUR AU - Schmieder, A. AU - Michel, J. AU - Schonhaar, K. AU - Goerdt, S. AU - Schledzewski, K. PY - 2012 DA - 2012// TI - Differentiation and gene expression profile of tumor-associated macrophages JO - Semin Cancer Biol VL - 22 UR - https://doi.org/10.1016/j.semcancer.2012.02.002 DO - 10.1016/j.semcancer.2012.02.002 ID - Schmieder2012 ER - TY - JOUR AU - Vinnakota, K. AU - Zhang, Y. AU - Selvanesan, B. C. AU - Topi, G. AU - Salim, T. AU - Sand-Dejmek, J. PY - 2017 DA - 2017// TI - M2-like macrophages induce colon cancer cell invasion via matrix metalloproteinases JO - J Cell Physiol VL - 232 UR - https://doi.org/10.1002/jcp.25808 DO - 10.1002/jcp.25808 ID - Vinnakota2017 ER - TY - JOUR AU - Cheng, R. AU - Sun, B. AU - Liu, Z. AU - Zhao, X. AU - Qi, L. AU - Li, Y. PY - 2014 DA - 2014// TI - Wnt5a suppresses colon cancer by inhibiting cell proliferation and epithelial-mesenchymal transition JO - J Cell Physiol VL - 229 UR - https://doi.org/10.1002/jcp.24566 DO - 10.1002/jcp.24566 ID - Cheng2014 ER - TY - JOUR AU - Dejmek, J. AU - Dejmek, A. AU - Safholm, A. AU - Sjolander, A. AU - Andersson, T. PY - 2005 DA - 2005// TI - Wnt-5a protein expression in primary dukes B colon cancers identifies a subgroup of patients with good prognosis JO - Cancer Res VL - 65 UR - https://doi.org/10.1158/0008-5472.CAN-05-1710 DO - 10.1158/0008-5472.CAN-05-1710 ID - Dejmek2005 ER - TY - JOUR AU - Sica, A. AU - Mantovani, A. PY - 2012 DA - 2012// TI - Macrophage plasticity and polarization: in vivo veritas JO - J Clin Invest VL - 122 UR - https://doi.org/10.1172/JCI59643 DO - 10.1172/JCI59643 ID - Sica2012 ER - TY - JOUR AU - Ma, X. AU - Meng, Z. AU - Jin, L. AU - Xiao, Z. AU - Wang, X. AU - Tsark, W. M. PY - 2017 DA - 2017// TI - CAMK2gamma in intestinal epithelial cells modulates colitis-associated colorectal carcinogenesis via enhancing STAT3 activation JO - Oncogene. VL - 36 UR - https://doi.org/10.1038/onc.2017.16 DO - 10.1038/onc.2017.16 ID - Ma2017 ER - TY - JOUR AU - Unudurthi, S. D. AU - Nassal, D. AU - Greer-Short, A. AU - Patel, N. AU - Howard, T. AU - Xu, X. PY - 2018 DA - 2018// TI - betaIV-Spectrin regulates STAT3 targeting to tune cardiac response to pressure overload JO - J Clin Invest VL - 128 UR - https://doi.org/10.1172/JCI99245 DO - 10.1172/JCI99245 ID - Unudurthi2018 ER - TY - JOUR AU - Rauner, M. AU - Stein, N. AU - Winzer, M. AU - Goettsch, C. AU - Zwerina, J. AU - Schett, G. PY - 2012 DA - 2012// TI - WNT5A is induced by inflammatory mediators in bone marrow stromal cells and regulates cytokine and chemokine production JO - J Bone Miner Res VL - 27 UR - https://doi.org/10.1002/jbmr.1488 DO - 10.1002/jbmr.1488 ID - Rauner2012 ER - TY - JOUR AU - Lasry, A. AU - Zinger, A. AU - Ben-Neriah, Y. PY - 2016 DA - 2016// TI - Inflammatory networks underlying colorectal cancer JO - Nat Immunol VL - 17 UR - https://doi.org/10.1038/ni.3384 DO - 10.1038/ni.3384 ID - Lasry2016 ER - TY - JOUR AU - Hai Ping, P. AU - Feng Bo, T. AU - Li, L. AU - Nan Hui, Y. AU - Hong, Z. PY - 2016 DA - 2016// TI - IL-1beta/NF-kb signaling promotes colorectal cancer cell growth through miR-181a/PTEN axis JO - Arch Biochem Biophys VL - 604 UR - https://doi.org/10.1016/j.abb.2016.06.001 DO - 10.1016/j.abb.2016.06.001 ID - Hai Ping2016 ER - TY - JOUR AU - Ye, K. AU - Chen, Q. W. AU - Sun, Y. F. AU - Lin, J. A. AU - Xu, J. H. PY - 2018 DA - 2018// TI - Loss of BMI-1 dampens migration and EMT of colorectal cancer in inflammatory microenvironment through TLR4/MD-2/MyD88-mediated NF-kappaB signaling JO - J Cell Biochem VL - 119 UR - https://doi.org/10.1002/jcb.26353 DO - 10.1002/jcb.26353 ID - Ye2018 ER - TY - JOUR AU - Wang, X. AU - Luo, G. AU - Zhang, K. AU - Cao, J. AU - Huang, C. AU - Jiang, T. PY - 2018 DA - 2018// TI - Hypoxic tumor-derived Exosomal miR-301a mediates M2 macrophage polarization via PTEN/PI3Kgamma to promote pancreatic Cancer metastasis JO - Cancer Res VL - 78 UR - https://doi.org/10.1158/0008-5472.CAN-17-3841 DO - 10.1158/0008-5472.CAN-17-3841 ID - Wang2018 ER - TY - JOUR AU - Pereira, C. AU - Schaer, D. J. AU - Bachli, E. B. AU - Kurrer, M. O. AU - Schoedon, G. PY - 2008 DA - 2008// TI - Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10 JO - Arterioscler Thromb Vasc Biol VL - 28 UR - https://doi.org/10.1161/ATVBAHA.107.157438 DO - 10.1161/ATVBAHA.107.157438 ID - Pereira2008 ER - TY - JOUR AU - Leandersson, K. AU - Riesbeck, K. AU - Andersson, T. PY - 2006 DA - 2006// TI - Wnt-5a mRNA translation is suppressed by the Elav-like protein HuR in human breast epithelial cells JO - Nucleic Acids Res VL - 34 UR - https://doi.org/10.1093/nar/gkl571 DO - 10.1093/nar/gkl571 ID - Leandersson2006 ER - TY - JOUR AU - Li, Z. AU - Zhang, K. AU - Li, X. AU - Pan, H. AU - Li, S. AU - Chen, F. PY - 2018 DA - 2018// TI - Wnt5a suppresses inflammation-driven intervertebral disc degeneration via a TNF-alpha/NF-kappaB-Wnt5a negative-feedback loop JO - Osteoarthr Cartil VL - 26 UR - https://doi.org/10.1016/j.joca.2018.04.002 DO - 10.1016/j.joca.2018.04.002 ID - Li2018 ER -