Fig. 6

Intraplantar administration of NGF reversed l-CDL-induced downregulation of p-JNK, p-ERK, p-p38, p-p65, TNF-α, and IL-1β in the DRG and sciatic nerve of CCI rats. The expression of p-ERK, p-p38 (a, d), p-JNK, p-p65 (b, e), TNF-α, and IL-1β (c, f) in the DRG and sciatic nerve in CCI rats after coadministration of NGF (0.1 μg/30 μL) and l-CDL (6 mg/kg) (NGF was administered 15 min before l-CDL treatment). n = 4 per group; ##P < 0.01, and ###P < 0.001, compared with the control group; *P < 0.05, **P < 0.01, and ***P < 0.001, compared with the CCI group; $P < 0.05, $$P < 0.01, and $$$P < 0.001, compared with the l-CDL group