Fig. 1

Perisciatic nerve administration of l-CDL on the operated side attenuated CCI-induced neuropathic pain. a, b Time course of the mechanical and thermal thresholds of SD rats at days 1, 3, 5, 7, 10, 14, and 20 after surgery compared with those of the control group. c, d Time course of the mechanical and thermal thresholds of SD rats after a single intramuscular injection of l-CDL (1.5, 3, and 6 mg/kg) around the muscles directly adjacent to the sciatic nerve on the operated side of CCI rats at day 15 after surgery (n = 6; *P < 0.05, **P < 0.01, and ***P < 0.001, compared with 0 h of each group; #P < 0.05, ##P < 0.01, and ###P < 0.001, compared with the control group). e, f Time course of the mechanical and thermal thresholds of SD rats after multiple injections of l-CDL (1.5, 3, and 6 mg/kg) around the muscles directly adjacent to the sciatic nerve on the operated side of CCI rats for 7 consecutive days. The mechanical and thermal thresholds were tested 2 h after l-CDL treatment each day (n = 6; *P < 0.05, **P < 0.01, and ***P < 0.001, compared with 14 d; #P < 0.05, and ##P < 0.01, compared with the control group)