From: TGF-β and WNT signaling pathways in cardiac fibrosis: non-coding RNAs come into focus
CircRNAs | Expression (up/down) | Function | model | Anti- fibrotic Pro-fibrotic | Reference |
---|---|---|---|---|---|
circRNA_010567 | Up | Regulated TGF-β signaling and ECM synthesis via sponging up miR-141 | Diabetic mice myocardium and CFs | Pro | [178] |
CircACTA2 | Up | Regulated the expression and function of α-SMA, by acting as a decoy for miR-548f-5p. TGF-β over-expression increased circACTA2. | Rat, mouse, and human VSMCs | Pro | [13] |