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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: PINOT: an intuitive resource for integrating protein-protein interactions

Fig. 4

PINOT: Performance & Sensitivity. a. The performance of PINOT was evaluated by assessing the number of interactors retrieved (gene names) upon submission of the reported query lists to PINOT (with stringent and lenient filtering), HIPPIE and MIST (on 18th September 2019). The databases were set to retrieve the maximum number of interactions (by removing all possible filters). HIPPIE and MIST were queried online and outputs were manually cleaned to remove interactions with i) no interaction detection method; ii) no PMID; iii) multiple Entrez IDs. The number of retained interactions retrieved is reported on top of each bar within the graphs. b. The number of interactions PINOT (with stringent and lenient filtering) and HIPPIE obtained when querying a seed list of 941 protein from Mitocarta 2.0. c. Comparison between PINOT and HIPPIE indicated that the vast majority of interactors (Entrez IDs) downloaded by the two tools was identical: 6790 common interactors for PINOT lenient (640 unique interactors) vs HIPPIE (355 unique interactors); 6572 common interactors for PINOT stringent (319 unique interactors) vs HIPPIE (573 unique interactors)

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