Fig. 7
From: Interleukin-12 elicits a non-canonical response in B16 melanoma cells to enhance survival
The ratio of IL12RB2 to IL12RB1 mRNA is increased in human malignant melanocytes compared to CD4+ and CD8+ T cells isolated from melanoma tumors. Single cells were isolated from 31 melanoma tumors and subject to single-cell RNA-seq analysis. a Scatter plot for IL12RB1 and IL12RB2 mRNA expression in TPM among malignant melanocytes (n = 2018, black), NK cells (n = 92, red), CD4+ T cells (n = 856, blue), and CD8+ T cells (n = 1759, yellow). b Using the subset with non-zero values for the expression of both genes, the distribution in the ratio of IL12RB2:IL12RB1 expression among malignant melanocytes (n = 418, black), NK cells (n = 22, red), CD4+ T cells (n = 187, blue), and CD8+ T cells (n = 181, yellow) is shown