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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Interleukin-12 elicits a non-canonical response in B16 melanoma cells to enhance survival

Fig. 6

STAT4 activation depends differently on the density of IL12 receptor complexes in 2D6 cells than in B16F0 cells while Akt activation in 2D6 and B16F0 cells exhibit similar dependence on the density of IL12 receptor complexes. Phosphorylation of STAT4 (panel a) and Akt (panel b) in 2D6 (o) and B16F0 (x) cells stratified by the density of IL12 receptor complexes: IL12RB1:IL12RB2 in 2D6 cells and IL12RB2:IL12RB2 in B16F0 cells. Colors indicate untreated cells (black) and stimulation with 7 (blue), 100 (red), and 300 (green) ng/mL of IL-12. The experimental results with the highest phosphorylation levels were regressed to Eq. 12 (black lines), with the resulting equation corresponding to the maximum likelihood fit indicated

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