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Table 5 Univariate and multivariate analyses of association of baseline prognostic factors with 5-year OS of patients with CRC

From: Effect of CIP2A and its mechanism of action in the malignant biological behavior of colorectal cancer

Variable

Univariate analysis

Multivariate analysis

P

5 year-OS

P

HR

CL (95%)

Gender

 

0.231

  

NS

 Female

82.8

    

 Male

69.6

    

Age

 

0.256

  

NS

 ≥ 65

61.3

    

 < 65

79.1

    

Location

 

0.166

  

NS

 Colon

60.2

    

 Rectum

73.7

    

T stage

 

0.000

  

0.029

 T1-T2

90.0

 

1

  

 T3-T4

49.8

 

8.905

1.256–63.182

 

N stage

 

0.004

  

NS

 N0

81.1

 

1

  

 N1-N2

50.0

 

6.225

0.454–85.377

 

M stage

 

0.000

  

NS

 M0

78.1

 

1

  

 M1

34.3

 

6.383

0.905–45.004

 

TNM stage

 

0.001

  

NS

 I-II

86.9

 

1

  

 III-IV

26.4

 

0.195

0.009–4.458

 

Histological grade

 

0.124

  

NS

 Well

90.9

    

 Moderately

72.7

    

 Poorly

48.5

    

CEA

 

0.003

  

NS

 ≥ 5

34.3

 

1

  

 < 5

76.7

 

1.344

0.269–6.711

 

CA19–9

 

0.117

  

NS

 ≥ 37

54.5

    

 < 37

67.1

    

CIP2A

 

0.043

  

0.052

 Low expression

75.4

 

1

  

 High expression

57.4

 

4.301

0.988–18.725

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