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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: GLI3: a mediator of genetic diseases, development and cancer

Fig. 1

Biochemical domains of GLI family members. Schematic diagram of the biochemical domains of human GLI1, GLI2 and GLI3 showing the relative repressor (RD), DNA binding and transactivation (TD) domains. HH-related transcriptional activator GLI1 is the smallest protein of the GLI family with 1106 AA (GLI2: 1586 AA; GLI3: 1580 AA). In comparison to GLI2 and GLI3, GLI1 lacks a transcriptional repressor domain. GLI1 and GLI2 isoforms have been described. There is no direct evidence to describe the exact position of the transactivation domain and zinc finger region of human GLI2

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