Fig. 7

Inhibition of OPN-αvβ3 axis suppresses HCC tumor growth and glycolyis. a Tumor volume in sh-Ctrl and sh-OPN HCC-LM3 xenografts as indicated time point was measured (n = 5). b Effect of Cilengitide treatment on the tumor growth of HCC-LM3 xenografts (n = 5). c The lactate level in the tumor tissues from (a) and (b) was detected (n = 5). d The expression of glycolytic genes in the tumor tissues from (a) and (b) was analyzed by real-time qPCR (n = 5). e Hematoxylin and eosin staining in liver tissue samples from tumor-bearing WT and OPN-KO mice. f The expression of glycolytic genes in liver tissue samples from tumor-bearing WT and OPN-KO mice was analyzed by real-time qPCR (n = 5). *P < 0.05 and **P < 0.01