Table 3 Regulatory factors of IL-9-producing cells in tumor immunity
Regulatory factor | Regulatory pathway way | Aim cell | Target tumor | Reference |
|---|---|---|---|---|
Dectin-1 activated DCs | TNFSF15 ↑ OX40L ↑ | Th9 ↑ | Melanoma | [82] |
GITR | TNFR-ralated Pr 6 NF-κB | Th9 ↑ | CT26-bearing Melanoma | [83] |
Autophage | Atg3 Atg5 | Th9 ↓ | / | [84] |
IL-7 | STAT5 PI3K-Akt-mTOR | Th9 ↑ | Melanoma | [85] |
Foxo1 | / | Th9 ↑ | Melanoma | [85] |
Foxp1 | / | Th9 ↓ | Melanoma | [85] |
Id3 | / | Th9 ↓ | melanoma | [86] |
SEB | HDAC1 ↑ PU.1 ↑ | Th9 ↑ | SqC | [87] |
GM-CSF | COX2/PGE | Th9 ↑ | / | [84] |
Cholesterol | LXR P65 | Tc9 ↓ | MC38-gp100-bearing | [42] |
TGF-β IL-15 | / | Vδ2 T ↑ | / | [80] |
IL-9 | / | Mast cell ↑ | melanoma |