From: Identification of a selective inhibitor of IDH2/R140Q enzyme that induces cellular differentiation in leukemia cells
Enzymes assayed
Incubation time (hours)
IC50 (nM)
CP-17
AGI-6780
Enasidenibc
IDH2/R140Qa
1
99.88
16.39
320
16
40.75
12.83
100
IDH2/WTb
2267
99.95
1800
Selectivity
55.6
7.8
18
IDH1/R132Ha
> 5000
IDH1/WTb