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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Identification of a selective inhibitor of IDH2/R140Q enzyme that induces cellular differentiation in leukemia cells

Fig. 4

Conformational changes of IDH2/WT bound with CP-17 after MD simulation. RMSD matrices of IDH2/R140Q_CP-17 a and IDH2/WT_CP-17 b systems during MD simulation. c Representation of surface maps of CP-17 bound IDH2/WT structure, with the catalytic sites of monomer A in an active closed conformation (left) and monomer B in an inactive open conformation (right)

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Cell Communication and Signaling

ISSN: 1478-811X