Fig. 3From: Identification of a selective inhibitor of IDH2/R140Q enzyme that induces cellular differentiation in leukemia cellsRepresentation of the surface maps of IDH2/R140Q_α-KG and IDH2/R140Q_CP-17. The α-KG-bound IDH2/R140Q structure with the catalytic site in the closed active conformation (left) versus the CP-17 bound IDH2/R140Q structure with the catalytic site in an inactive open conformation (right)Back to article page