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Table 6 Genes differentially regulated in 3D CAF spheroids compared to 2D culture

From: Cancer-associated fibroblasts promote prostate tumor growth and progression through upregulation of cholesterol and steroid biosynthesis

Inflammation

IL1B

Interleukin 1, beta

PTGS2

Prostaglandin-endoperoxide synthase 2

CXCL5

Chemokine (C-X-C motif) ligand 5

IL11

Interleukin 11

IL24

Interleukin 24

CXCL2

Chemokine (C-X-C motif) ligand 2

IL13RA2

Interleukin 13 receptor, alpha 2

IL6

Interleukin 6

CCL20

Chemokine (C-C motif) ligand 20

IL24

Interleukin 24

IL8

Interleukin 8

IL1A

Interleukin 1, alpha

IL33

Interleukin 33

CCL7

Chemokine (C-C motif) ligand 7

IRAK2

Interleukin-1 receptor-associated kinase 2

IL18R1

Interleukin 18 receptor 1

IL1R1

Interleukin 1 receptor, type I

TNFAIP3

Tumor necrosis factor, alpha-induced protein 3

CCRL1

Chemokine (C-C motif) receptor-like 1

LOC651872

C-C chemokine receptor type 11 (C-C CKR-11)

ISG20

Interferon stimulated exonuclease gene 20 kDa

CXCL1

Chemokine (C-X-C motif) ligand 1

IL4R

Interleukin 4 receptor

TNFAIP6

Tumor necrosis factor, alpha-induced protein 6

IL1RN

Interleukin 1 receptor antagonist

INSIG1

Insulin induced gene 1

TNFSF10

Tumor necrosis factor (ligand) superfamily, member 10

CCL3L1

Chemokine (C-C motif) ligand 3-like 1

PTGER4

Prostaglandin E receptor 4 (subtype EP4)

IL1F9

Interleukin 1 family, member 9

CCL3L1

Chemokine (C-C motif) ligand 3-like 1

IL7R

Interleukin 7 receptor

IL23A

Interleukin 23, alpha subunit p19

IFRD1

Interferon-related developmental regulator 1

INSIG2

Insulin induced gene 2

ECM-receptor interaction

TNC

Tenascin C (hexabrachion)

LAMB3

Laminin, beta 3

THBS2

Thrombospondin 2

COL4A6

Collagen, type IV, alpha 6

COL4A1

Collagen, type IV, alpha 1

ITGA2

Integrin, alpha 2 (CD49B)

COL4A2

Collagen, type IV, alpha 2

Fatty acid metabolism

ACSL4

Acyl-CoA synthetase long-chain family member 4

ACADVL

Acyl-Coenzyme A dehydrogenase, very long chain

ACSL1

Acyl-CoA synthetase long-chain family member 1