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Table 5 Differentially regulated genes annotated to steroid biosynthesis in Du/CAF co-culture spheroids

From: Cancer-associated fibroblasts promote prostate tumor growth and progression through upregulation of cholesterol and steroid biosynthesis

Symbol

Fold change

Name

AKR1C4

6.77

Aldo-keto reductase family 1, member C4

HSD11B2

5.37

Hydroxysteroid (11-beta) dehydrogenase 2

UGT1A1

5.22

UDP glucuronosyltransferase 1 family, polypeptide A1

AKR1C3

4.06

Aldo-keto reductase family 1, member C3

UGT1A3

3.04

UDP glucuronosyltransferase 1 family, polypeptide A3

DHCR7

2.31

7-dehydrocholesterol reductase

DHCR24

2.54

24-dehydrocholesterol reductase

LSS

2.34

Lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)

HSD17B7

2.11

Hydroxysteroid (17-beta) dehydrogenase 7

SC4MOL

2.41

Sterol-C4-methyl oxidase-like

SC5DL

2.60

Sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like

UGT2B11

2.31

UDP glucuronosyltransferase 2 family, polypeptide B11

CYP3A5

2.61

Cytochrome P450, family 3, subfamily A, polypeptide 5

HSD17B7

2.11

Hydroxysteroid (17-beta) dehydrogenase 7

UGT2B7

2.74

UDP glucuronosyltransferase 2 family, polypeptide B7

UGT2B10

2.57

UDP glucuronosyltransferase 2 family, polypeptide B10

UGT2B17

2.53

UDP glucuronosyltransferase 2 family, polypeptide B17

UGT1A6

0.42

UDP glucuronosyltransferase 1 family, polypeptide A6