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Table 2 Genes similarly regulated in LNCaP and DuCaP 3D spheroids compared to 2D culture

From: Cancer-associated fibroblasts promote prostate tumor growth and progression through upregulation of cholesterol and steroid biosynthesis

 

fold change 3D vs 2D

 

Symbol

LNCaP

DuCaP

Name

ANKHD1

2.00

2.38

ankyrin repeat and KH domain containing 1

CCPG1

2.47

2.78

cell cycle progression 1

FERMT2

2.43

5.05

fermitin family member 2

GDF15

2.40

11.10

growth differentiation factor 15

HSPH1

2.13

2.31

heat shock protein family H, member 1

LARP6

3.82

2.51

La ribonucleoprotein domain family member 6

MYLIP

2.32

2.05

myosin regulatory light chain interacting protein

PLAUR

2.03

2.93

plasminogen activator, urokinase receptor

PPARG

2.15

11.33

peroxisome proliferator-activated receptor gamma

SAT1

2.41

3.07

spermidine/spermine N1-acetyltransferase 1

SH3GLB1

2.11

3.50

SH3-domain GRB2-like endophilin B1

SLC3A2

2.23

3.51

solute carrier family 3 (amino acid transporter heavy chain), member 2

SPIRE1

2.86

2,44

spire-type actin nucleation factor 1

SQSTM1

2.57

3.00

sequestosome 1

TRIB3

2.34

2.08

tribbles pseudokinase 3

UPP1

2.39

2.62

uridine phosphorylase 1

ZFAND2A

2.04

2.11

zinc finger, AN1-type domain 2A

ZYX

3.61

4.09

zyxin

CDC45L

0.17

0.45

cell division cycle 45

CHEK1

0.41

0.48

checkpoint kinase 1

E2F2

0.36

0.43

E2F transcription factor 2

EGR1

0.15

0.10

early growth response 1

FOS

0.10

0.04

FBJ murine osteosarcoma viral oncogene homolog

FOXM1

0.47

0.31

forkhead box M1

GINS2

0.25

0.44

GINS complex subunit 2 (Psf2 homolog)

H2AFX

0.46

0.38

H2A histone family member X

HMMR

0.18

0.49

hyaluronan mediated motility receptor

ID3

0.45

0.25

inhibitor of DNA binding 3, dominant negative helix-loop-helix protein

KIAA0101

0.29

0.48

KIAA0101

KIF11

0.44

0.49

kinesin family member 11

LOC731314

0.27

0.37

similar to H2A histone family, member X

NCAPD2

0.46

0.45

Condensin complex subunit 1

PFKFB4

0.43

0.45

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

SLC45A3

0.41

0.42

solute carrier family 45 member 3

TK1

0.30

0.44

thymidine kinase 1, soluble

TYMS

0.26

0.49

thymidylate synthetase

UHRF1

0.31

0.43

ubiquitin-like with PHD and ring finger domains 1

TPX2

0.44

0.40

TPX2, microtubule-associated

TUBA1A

0.37

0.46

tubulin alpha 1a