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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Cancer-associated fibroblasts promote prostate tumor growth and progression through upregulation of cholesterol and steroid biosynthesis

Fig. 4

HMGCS2 and AKR1C3 expression is significantly increased in human PCa. a, b Representative staining for HMGCS2 and AKR1C3 in benign (BPH) prostate tissue and PCa. Staining intensity was quantified by determining H-score in the epithelium (ep) (a) and in the stroma (str) (b) as described under methods. c Expression of HMGCS2 and AKR1C3 was correlated with Gleason score (GSC) (GSC ≤ 6: N = 12, GSC = 7: N = 31, GSC ≥ 8: N = 19) and (d) lymph node metastases (N0: N = 41, N1: N = 20). Data are represented as mean + SEM. (* P < 0.05, *** P < 0.001)

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Cell Communication and Signaling

ISSN: 1478-811X