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Fig. 9 | Cell Communication and Signaling

Fig. 9

From: miR-544 promotes maturity and antioxidation of stem cell-derived endothelial like cells by regulating the YY1/TET2 signalling axis

Fig. 9

iECICs are effective in improving antioxidation and plaque deposits in ApoE−/− and atherosclerotic mice model. a HE staining of tissues. Magnification: 200×. Plague area test. *p < 0.05 vs. ApoE−/− mice transplanted with miR-mut-iECICs; t test; n = 6. b Masson staining of tissues. Magnification: 200×. c ATP levels in vascular endothelial cells of abdominal aorta of ApoE−/− mice transplanted with miR-544-iECICs or miR-mut-iECICs and fed with high-fat diet. *p < 0.05 vs. ApoE−/− mice transplanted with miR-mut-iECICs; t test; n = 6. d SOD levels in vascular endothelial cells of abdominal aorta of ApoE−/− mice transplanted with miR-544-iECICs or miR-mut-iECICs and fed with high-fat diet. **p < 0.01 vs. ApoE−/− mice transplanted with miR-mut-iECICs; t test; n = 6. e Flow cytometry showing the proportions of ROS-positive vascular endothelial cells of abdominal aorta of ApoE−/− mice transplanted with miR-544-iECICs or miR-mut-iECICs and fed with high-fat diet. *p < 0.05 vs. ApoE−/− mice transplanted with miR-mut-iECICs; t test

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