Fig. 1
From: Chitinase 3 like 1 suppresses the stability and activity of p53 to promote lung tumorigenesis
Chi3L1KO(−/−) mice in lung metastasis In Vivo. a, b B16F10 cells were injected by a single i.v. injection (1 × 104 cells) to induce lung metastasis. At the time of sacrifice, lungs were lavaged (a) and used for surface tumor number and diameter measurements (b). The results are expressed as mean ± ± SEM. *, p < 0.05 compared to wild type mice. c Tissue extracts were analyzed by Western blotting. Samples were resolved on SDS-PAGE, and detected with antibodies against Chi3L1, p53, p21, Cyclin E1, phoshp-STAT3, STAT3, Cdk2, BAX, Caspase3, and β-actin. Data shown represent mean ± SEM