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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: Cell death induced by the ER stressor thapsigargin involves death receptor 5, a non-autophagic function of MAP1LC3B, and distinct contributions from unfolded protein response components

Fig. 8

The IRE1-XBP1 axis is required for the second phase of JNK activation by Tg in LNCaP cells. LNCaP cells were transfected for 2 d with the indicated siRNAs (siCtrl = non-targeting control siRNA), employing two different siRNA oligoes for each target (designated by − 1 and − 2). Subsequently, cells were treated with 100 nM Tg or 0.01% DMSO vehicle control (also transfected with siCtrl) for 30 min, 6 h, or 30 h, and subjected to western blotting with the indicated antibodies; p-JNK = phospho-JNK, cl-PARP = cleaved PARP

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Cell Communication and Signaling

ISSN: 1478-811X