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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: mTOR may interact with PARP-1 to regulate visible light-induced parthanatos in photoreceptors

Fig. 8

PARP-1/mTOR inhibition attenuates light-induced retina ONL thinning. Mice were intraperitoneally injected with 20 mg/kg 3AB or 15 mg/kg rapamycin for 7 days following 7000 lx light exposure for 12 h. Mice were sacrificed and retinas were sectioned for histopathological analysis. a histopathological analysis of mice retina. Scale bar = 20 μm. b Quantification of ONL thickness. c Quantification of photoreceptor nuclei. All experiments were repeated in triplicate, and the results are shown as the means ± SEM (**: P < 0.01, ***: P < 0.001)

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