Fig. 6
From: mTOR may interact with PARP-1 to regulate visible light-induced parthanatos in photoreceptors
PARP/mTOR inhibitors attenuate the light-induced activation of PARP-1/mTOR signals in mice retina. Mice were intraperitoneally injected with 20 mg/kg 3AB or 15 mg/kg rapamycin for 7 days following 7000 lx light exposure for 12 h. a The mice were sacrificed 5 days after light exposure, and retinal samples were analyzed by Western blot. β-ACTIN was used as an internal control. RAPA: rapamycin, an mTOR inhibitor; 3AB: a PARP-1 inhibitor; Lt: 7000 lx light exposure for 12 h. b–g Quantitative analysis of target protein levels related to β-ACTIN. All experiments were repeated in triplicate, and the results are shown as the means ± SEM (*: P < 0.05, **: P < 0.01, ***: P < 0.001)