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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: The let-7 family of microRNAs suppresses immune evasion in head and neck squamous cell carcinoma by promoting PD-L1 degradation

Fig. 7

The molecular mechanism involved in let-7 family of miRNAs regulating the immune evasion of HNSCC by mediating TCF-4, β-Catenin/STT3 pathway and PD-L1. Let-7 family of miRNAs inhibited the expression of TCF-4, suppressed β-Catenin/STT3-mediated PD-L1 glycosylation, reduced PD-L1 stability, promoted the ubiquitination and degradation of PD-L1, and improved the recognition ability of T cells to HNSCC cells. miRNAs, microRNAs; HNSCC, squamous cell carcinoma of the head and neck; TCF-4, transcription factor 4; PD-L1, programmed death-ligand 1

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Cell Communication and Signaling

ISSN: 1478-811X