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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: The let-7 family of microRNAs suppresses immune evasion in head and neck squamous cell carcinoma by promoting PD-L1 degradation

Fig. 4

Over-expressed let-7 represses cell immune tolerance but improves the cell apoptosis of HNSCC. a the expression of cleaved-caspase3 in FADU cells after treatment with over-expressed let-7a/let-7b/TCF-4 and co-culturing with PBMCs examined by flow cytometry. b the expression of cleaved-caspase3 in FADU cells after treatment with over-expressed let-7a/let-7b/TCF-4, co-culturing with PBMCs and combining with CTLA-4 antibody examined by flow cytometry. * p < 0.05 compared with the control group. The results were measurement data and were expressed as mean ± standard deviation. Data among multiple groups were analyzed by ANOVA, with Tukey’s post hoc test conducted. The experiment was repeated three times. HNSCC, squamous cell carcinoma of the head and neck; PBMCs, peripheral blood monouclear cells; TCF-4, transcription factor 4; ANOVA, analysis of variance; CTLA-4, cytotoxic T-lymphocyte-associated antigen 4

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Cell Communication and Signaling

ISSN: 1478-811X