Fig. 3From: The let-7 family of microRNAs suppresses immune evasion in head and neck squamous cell carcinoma by promoting PD-L1 degradationLet-7 family of miRNAs represses β-catenin/STT3 pathway by targeting TCF-4. a the binding sequences between let-7 family of miRNAs and TCF-4. b the binding of TCF-4 WT/MUT and let-7a/7b examined by dual-luciferase reporter gene assay. c the TCF-4 expression in FADU cells treated with over-expressed let-7a/7b examined by western blot analysis. d the expression of PD-L1 and β-Catenin/STT3 pathway-related factors in FADU cells after over-expression of let-7a/7b as well as TCF-4 examined by western blot analysis. * p < 0.05 compared with the control group. The results were measurement data and were expressed as mean ± standard deviation. Data among multiple groups were analyzed by ANOVA, with Tukey’s post hoc test conducted. The experiment was repeated three times. TCF-4, transcription factor 4; WT, wild type; MUT, mutant type; PD-L1, programmed death-ligand 1; ANOVA, analysis of variancBack to article page