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Table 6 Comparison of the anti-nRNP IgG and anti-dsDNA IgG levels of mice in each group

From: 1,25-(OH)2D3/Vitamin D receptor alleviates systemic lupus erythematosus by downregulating Skp2 and upregulating p27

Group

Anti-nRNP IgG

Anti-dsDNA IgG

0 W (n = 10)

24 W (n = 10)

0 W (n = 10)

24 W (n = 10)

Control

0.51 ± 0.09

0.62 ± 0.06

0.12 ± 0.04

0.15 ± 0.05

VDR−/−

0.56 ± 0.08

1.13 ± 0.16*$

0.16 ± 0.01

0.45 ± 0.10*$

SLE

1.12 ± 0.17*

1.25 ± 0.13*

0.61 ± 0.07*

0.52 ± 0.11*

SLE + VD3

1.19 ± 0.05*

0.81 ± 0.21#$

0.63 ± 0.12*

0.28 ± 0.02#$

SLE + VD3 + VDRinsert

1.23 ± 0.12*

0.65 ± 0.15#$

0.69 ± 0.14*

0.18 ± 0.03#$

  1. Notes: one-way analysis of variance was performed to analyze data; * p < 0.05 compared with the control group; # p < 0.05 compared with the SLE group; the paired t-test was performed to analyze data; $ p < 0.05 compared with the 0 W; SLE systemic lupus erythematosus, IgG immunoglobulin G; VDR vitamin D receptor
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Cell Communication and Signaling

ISSN: 1478-811X