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Table 5 Comparisons of inflammatory factors (IL-4, IL-10, IL-17 and INF-γ) of mice in each group (pg/mL)

From: 1,25-(OH)2D3/Vitamin D receptor alleviates systemic lupus erythematosus by downregulating Skp2 and upregulating p27

Group

IL-4

IL-10

IL-17

INF-γ

0 W (n = 10)

24 W (n = 10)

0 W (n = 10)

24 W (n = 10)

0 W (n = 10)

24 W (n = 10)

0 W (n = 10)

24 W (n = 10)

Control

9.24 ± 3.0

9.52 ± 2.01

30.12 ± 7.58

34.98 ± 8.14

8.73 ± 2.41

7.51 ± 2.50

11.93 ± 0.78

11.33 ± 1.37

VDR−/−

9.70 ± 3.14

20.55 ± 4.18*$

36.12 ± 7.04

79.39 ± 7.30*$

8.45 ± 1.47

13.95 ± 2.68*$

12.29 ± 4.77

23.65 ± 5.12*$

SLE

35.80 ± 6.02*

38.39 ± 2.56*

82.08 ± 13.35*

90.44 ± 10.83*

15.76 ± 3.83*

16.27 ± 3.10*

29.92 ± 7.81*

32.67 ± 4.58

SLE + VD3

34.71 ± 3.64*

12.27 ± 3.55#$

83.27 ± 11.44*

43.74 ± 4.83#$

15.60 ± 2.96*

9.77 ± 5.28#$

28.71 ± 5.10*

14.94 ± 3.13*#$

SLE + VD3 + VDRinsert

34.14 ± 3.11*

11.79 ± 1.84#$

81.59 ± 9.20*

41.69 ± 5.18#$

15.02 ± 3.62*

8.40 ± 2.02#$

28.62 ± 2.72*

14.32 ± 2.11#$

  1. Notes: one-way analysis of variance was performed to analyze data; * p < 0.05 compared with the healthy controls; # p < 0.05 compared with the SLE group; the paired t-test was performed to analyze data; $ p < 0.05 compared with the 0 W; SLE systemic lupus erythematosus, IL Interleukin, INF Interferon, VDR vitamin D receptor