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Table 4 Comparisons of the blood biochemical indicators of mice in each group

From: 1,25-(OH)2D3/Vitamin D receptor alleviates systemic lupus erythematosus by downregulating Skp2 and upregulating p27

Biochemical indicators

Control (n = 10)

VDR−/− (n = 10)

SLE

(n = 10)

SLE + VD3

(n = 10)

SLE + VD3 + VDRinsert

(n = 10)

BUN

 0 W

5.32 ± 0.71

5.48 ± 0.25

13.03 ± 1.60*

12.76 ± 0.54*

12.22 ± 0.40*

 24 W

5.26 ± 0.54

9.53 ± 0.37*$

13.76 ± 1.12*

6.95 ± 0.65#$*

5.72 ± 0.58#$

Cr

 0 W

22.24 ± 2.54

22.80 ± 1.06

35.87 ± 1.15*

35.38 ± 1.22*

34.62 ± 1.27*

 24 W

20.93 ± 1.08

30.43 ± 1.46$

37.09 ± 1.59*

25.06 ± 1.51#$*

22.04 ± 0.67#$

Urine protein (μg/mL)

 0 W

45 ± 10

43 ± 6

86 ± 11*

88 ± 15*

86 ± 17*

 24 W

48 ± 11

77 ± 12*$

91 ± 14*

62 ± 14*#$

57 ± 13*#$

  1. Notes: one-way analysis of variance was performed to analyze data; * p < 0.05 compared with the control group; # p < 0.05 compared with the SLE group; the paired t-test was performed to analyze data; $ p < 0.05 compared with the 0 W; SLE systemic lupus erythematosus, VDR vitamin D receptor; BUN blood urea nitrogen, Cr creatinine