Skip to main content
Fig. 8 | Cell Communication and Signaling

Fig. 8

From: TRIM30 modulates Interleukin-22-regulated papillary thyroid Cancer cell migration and invasion by targeting Sox17 for K48-linked Polyubiquitination

Fig. 8

A hypothetical model for the role of TRIM30 in IL-22-regulated PTC cell migration and invasion. Under IL-22 treatment, TRIM30 associates with Sox17 for K48-linked polyubiquitination, thereby impairing the interaction between Sox17 and β-catenin. As a result, β-catenin translocates from the cytosol to the nucleus and activates downstream signaling, consequently contributing to PTC development

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X